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KMID : 0354719900140020185
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Journal of Korean Diabetes Association
1990 Volume.14 No. 2 p.185 ~ p.189
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Fasting Serum C-Peptide, GlucagonStimulated Serum C-Peptide and Urinary C-Peptide in Clinical Classification of Diabetes
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Abstract
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We studies fasting serum C-peptide, glucagon stimulated serum C-peptide, and 24h urinary C-peptide in relation to clinical type of diabetes. Patients were classified as typical IDDM in the presence of the following criteria: 1) age of diagnosis ≤ 40 years, 2) body mass index below 25, 3) positive urine or plasma ketone bodies and/or 4) insulin treatment started within one year after diatnosis. Paients were classified as typical NIDDM in the presence of the fllowing criteria: 1) age of diagnosis v 40 yeaes, 2) body mass index ≥ 20, 3) negative urinary ketone bodies and 4) no history of insulin treatment (for at least 1 year after diagnosis). Among 17 patients with typical IDDM, fasting serum C-peptide levels were below 0.6ng/㎖ in 13 patients and were higher than 1.0ng/㎖ in 3 patients. Fasting serum C-peptide levels were also hiher than 1.0ng/㎖ in 83 out of 85 typical NIDDM patients and were below 0.6ng/㎖ in only 1 out of 85 patients. Postglucagon C-peptide levels were below 1.0v in 9 out of 14 IDDM patients and were higher than 1.8ng/㎖ in 38 out of 40 NIDDM patients. 24h urinary C-peptide exeretion was less than 10 ㎕ in 7 out of 16 IDDM patients and was more than 30 ㎕ in 47 out of 56 NIDDM patients. From these results, we conclude that fasting serum C-peptide gives a good distinction between IDDM and NIDDM.
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KEYWORD
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